Polarographic Determination of Ascaridol in Chenopodium Oil

Deterioration of Ascaridol in Oil of Chenopodium

Before the advent of carbon tetrachloride and tetrachlorethylene, oil of chenopodium was largely used in the treatment of hookworm infection all over the world. Though the oil was made official in the U.S.A. Pharmacopoeia long ago, it was not until 1932 that it found its place in the British Pharmacopoeia. According to the Pharmacopoeias of both the countries, the oil should contain not less th...

Effect of Heat and Light on the Ascaridol Content in Oil of Chenopodium

Polarographic determination of malononitrile.

A procedure is proposed for the determination of malononitrile by differential pulse polarography in methanolic 0.1M tetraethylammonium iodide/0.001M tetramethylammonium hydroxide as the supporting electrolyte. In this medium malononitrile is chemically converted into an electroactive species. With close control of timing of the steps in the procedure the error of the method is +/-1.5% in the c...

The polarographic determination of selenium in urine.

Polarographicdata are presented for the reduction of selenite ion in 3M sulfuric acid, 1M potassium chloride, and 1M ammonia-ammonium chloride. In these first two media two waves are obtained correspondingto the diffusion-controlled reduction of selenite ion to selenium amalgam and the adsorption of selenite ion on the mercury drop, respectively. One wave is obtained in ammonia-ammonium chlorid...

Activity of ascaridol from the anthelmintic herb Chenopodium anthelminticum L. against sensitive and multidrug-resistant tumor cells.

Ascaridol is the active principle of the American wormseed Chenopodium anthelminticum L. We isolated ascaridol from a commercial preparation of Chenopodium oil and analyzed its activity against different tumor cell lines in vitro (CCRF-CEM, HL60, MDA-MB-231). Multidrug-resistant (MDR) counterparts of these cell lines express differentially the MDR-conferring ATP-binding cassette transporter gen...